肿瘤干细胞与正常干细胞有很多相似的特点，如二者都具有自我更新、可以产生大量分化细胞及拥有一些共同的表面标记。所不同的是正常干细胞在有序的调控下发挥自己的功能，如在正常的生理条件下，造血干细胞受到细胞周期调控因子p21与p18的调节，大部分时间都处于静止状态，当造血干细胞收到外界信号刺激后，才会进入自我更新或分化进程，维持组织的更新与修复，整个过程处于平衡状态。而肿瘤干细胞分裂与分化是失控的，通过不断自我更新与分化，最终产生大量的肿瘤细胞，维持着肿瘤的生长与异质性。

Novus提供大量与肿瘤干细胞研究相关的产品，方便广大科研用户。

Catalog：H6-NBP1-77687 Product: ABCB5 Antibody Species: Hu, Mu Applications: IF, ICC, IHC-P		Catalog：H6-NB600-1071 Product: CD34 (MEC 14.7) Antibody Species: Mu Applications: ELISA, FACS, ICC, IF, IHC-Fr, IHC-P, IP, WB
Catalog：H6-NBP1-44703 Product: CD34 (QBEnd-10) Antibody Species: Hu, Mk Applications: Func, FACS, IHC-Fr, IHC-P, IP, WB		Catalog：H6-NBP1-86010 Product: CD38 Antibody Species: Hu Applications: IHC-P, WB
Catalog：H6-NBP1-31488 Product: CD44 Antibody Species: Hu Applications: : ICC, IF, IHC-P, WB		Catalog：H6-NBP1-42067 Product: CD90/Thy1 (EPR3132) Antibody Species: Hu, Rt Applications: ICC, IHC-P, WB
Catalog：H6-NBP1-47729 Product: EpCAM (4G10) Antibody Species: Hu Applications: : IF, IHC-P, WB		Catalog：H6-NBP1-95700 Product: EpCAM Antibody (EPR677(2)) Species: Hu Applications: ICC, IHC-P, W
Catalog：H6-M-009-100 Product: p75 NGF Receptor (MLR2) Antibody Species: GP, Hu, Mu, Rt Applications: FACS, IF, IHC-Fr, WB		相关指标 ABCB5CD44 CD24CD90 CD34EpCAM CD38p75 NGF Recepto

产品引用文献：

1.[CD34 Antibody NB600-1071) Fiorina P, Pietramaggiori G, Scherer SS, et al. The mobilization and effect of endogenous bone marrow progenitor cells in diabetic wound healing. Cell Transplant. 2010;19(11):1369- 81. [PMID: 20977829]

2.[CD34 Antibody NB600-1071] Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9.

3.[CD44 Antibody AP00142PU-N] Walker F, Zhang H-H, Odorizzi A, Burgess AW. LGR5 Is a Negative Regulator of Tumorigenicity, Antagonizes Wnt Signalling and Regulates Cell Adhesion in Colorectal Cancer Cell Lines. PLoSONE. 201. [PMID 21829496]

4.[EpCAM Antibody NB110-56958] Kalabis J, Oyama K, Okawa T, Nakagawa H, Michaylira CZ, Stairs DB, Figueiredo JL, Mahmood U, Diehl JA, Herlyn M, Rustgi AK. A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification. J Clin Invest. 2008 Dec;118(12):3860-9.

5.[EpCAM Antibody NB110-56958] Ralhan R, Cao J, Lim T, et al, EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis ,BMC Cancer 10 (2010) 331

6.[EpCAM Antibody NB110-56958] Maetzel D, Denzel S, Mack B, et al, Nuclear signalling by tumor-associated antigen EpCAM ,Nature Cell Biology11 (2009) 162-171. (IP)

7.[p75 NGF Receptor Antibody M-009-100] Wiese S, Herrmann T, Drepper C, Jablonka S, Funk N, Klausmeyer A, Rogers ML, Rush RA & Sendtner M (2009) Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos. Nat Protoc. 2010;5(1):31-8

8.[p75 NGF Receptor Antibody M-006-100 and NGF Receptor Antibody NB100-1539] Davies A. et al (2010) The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a post translational modification essential for function Proc Natl Acad Sci U S A. Jan 26;107(4):1654-9

​​​​​​​联科生物代理截止时间：2017年6月30日